Calcium carbide (CaC2) is known for its wide applications in the production of acetylene and calcium cyanamide, whereas praseodymium Oxide (Pr6O11) is used in sensors and high-temperature pigments. The present study was designed to evaluate the effect of biofield energy treatment on the physical and structural properties of CaC2 and Pr6O11 powder. The powder samples of both compounds were equally divided into two parts, referred as control and treated. The treated part of both compounds was subjected to Mr. Trivedi’s biofield energy treatment. After that, both control and treated samples were investigated using X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy. The XRD data revealed that the biofield energy treatment has increased the lattice parameter of unit cell by 3.35% in the treated CaC2 sample as compared to the control. The density of treated CaC2 sample was reduced upto 4.49% and molecular weight was increased upto 4.70% as compared to the control. The crystallite size of CaC2 was reduced from 98.19 nm (control) to 52.93 nm in the treated CaC2 sample as compared to the control. The FT-IR analysis exhibited that the absorption band attributed to C=C stretching vibration was shifted to higher wavenumber as compared to the control. Thus, above data suggested that biofield energy treatment has considerable impact on the physical and structural properties of CaC2. Besides, in Pr6O11, the XRD did not show any significant change in lattice parameter, density and molecular weight. However, the FT-IR spectra revealed that the absorption band attributing to Pr-O stretching vibration was shifted from 593 cm-1 (control) to higher wavenumber 598 cm-1 in the treated Pr6O11 sample. Therefore, the biofield energy treatment could be applied to modify the CaC2 and Pr6O11 powder for the use in chemical industries.