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30 SÖFW-Journal |134|5-2008 COSMETICS STEMCELLS cellsandadultstemcells.Embryonic stemcellsarepluripotentandthuscan differentiateintoallcelltypesofthe body.Theroleofadultstemcellsisto maintainandrepairtissues.Theyare morerestrictedandnormallyabletodif- ferentiateonlyintothedifferentcell typesofthetissueinwhichtheyare found.Butthereexistalsoadultstem cellswithapluripotentdifferentiation potential.Theyarethefocusofthe newestresearchbecausethereareno ethicalconcernswithadultstemcells. Eachcell,whetherstemcellordifferen- tiatedcell,hasthesameDNA,meaning thesamegenes.Sowhatmakesastem cellastemcell?Theircharacteristicsde- pendonsignalsfromthemicroenvirone- D.Schmid,C.Schürch,P.Blum,E.Belser,F.Zülli * PlantStemCellExtractforLongevity ofSkinandHair Keywords:stemcells,anti-aging,plantcellculture,senescence,hairfollicles Introduction WhatareStemCells? Stemcellsareunprogrammedcellsthat candifferentiateintocellswithspecific functions.Stemcellshavethereforea bigpotentialinregenerativemedicine. Regenerativetherapiesareusedtostimu- latehealingandmightbeusedinthefu- turetotreatParkinson’s,Alzheimer’sor diabetes.Regenerativemedicinewillre- sultinanextendedhealthylifespan.Stem cellresearchisnowafascinating,hot topicthatisalreadyusedincosmetics. Amatokin,afacecareproductlineofVoss Laboratories,isclaimedtostimulatethe stemcellsintheskin.AndDior’sCapture R60/80XPrangeareanti-wrinkleprod- uctswhosemechanismofactionisbased onprotectionofthelifeforceofstem cells. Sowhatexactlyarestemcells?Themain principlesthatdefinestemcellpopula- tionsinclude:(I)thecapacitytoreplen- ishthemselvesthroughself-renewaland (II)theabilitytogeneratedifferentiated cells.Therearetwotypesofstemcellsin animalsandhumans:embryonicstem S temcellsofanoldapplecul- tivarwithverygoodstorage propertieswereproducedby applyingplantcellculturetechni- que.Theextractofthecultured applestemcellswasshowntoen- hancetheviabilityofumbilical cordbloodstemcells,toreverse senescencesignsinhumanfibrob- lastcellsandtoincreaselifespan ofisolatedhumanhairfollicles. PhytoCellTech™MalusDomestica, acosmeticingredientbasedon encapsulatedextractofcultured applestemcells,wastestedina clinicaltrialover4weekswith20 subjects.Thisnewingredientwas foundtosignificantlyreducewrin- klesinthecrow’sfeetarea. Summary Fig.1 Thehairbulgecontainsmultipotentstemcellsthatcontributetothelin- eagesoftheepidermis,thesebaceousglandandthehairfollicle Epidermallayer Basallayer Outerrootsheath Innerrootsheath Hairshaft Hairfolliclematrix Dermalpapilla Sebaceousgland Hairbulge stemcells
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