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UNIFORMITY OF DIAMETER, THICKNESS AND HARDNESS Experiment 1 : Tablet diameter is determined by the machine tooling used to produce them. Machine tooling involves a die plus an upper and a lower punch. This is called a station of tooling. The thickness is determined by the amount of tablet material and the position of the punches in relation to each other during compression. The corresponding pressure applied during compression can also be measured. The shorter the distance between the punches, the thinner the tablet, the greater the pressure applied during compression, and this will sometimes cause the hardening the tablet. Tablets need to be hard enough that they don't break up in the bottle, yet friable enough that they will disintegrate in the gastric tract. Introduction:
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